Larance Ronsard, Ph.D.

• I have been working on HIV-1 genetics in relation to pathogenesis and infection to make protective epitopes using a wide range of tools including sequence based profiles, phylogenetic and recombination analysis, siRNA based targeting and structural biology of viral proteins.
• In parallel, i have worked on functional implications of viral genes based on natural substitutions exhibited by virus.
• My long term goal is to understand the role of viral and host genetics on HIV-1 biology with respect to progression and to develop the effective therapeutics against HIV/AIDS. 

Publications:

1. Genetic and functional characterization of HIV-1 Vif on APOBEC3G degradation: First report of emergence of B/C recombinants from North India.
2. BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF- k B pathway—A comparative study with curcumin.
3. Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways.
4. Impact of genetic variations in HIV-1 Tat on LTR-mediated transcription via TAR RNA interaction..
5. Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice.
6. Molecular and Genetic Characterization of Natural HIV-1 Tat Exon-1 Variants from North India and Their Functional Implications.
7. Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin - An in vitro and in silico approach.
8. Effect on HIV-1 Gene Expression, Tat-Vpr Interaction and Cell Apoptosis by Natural Variants of HIV-1 Tat Exon 1 and Vpr from Northern India.
9. Genetic Characterization of Natural Variants of Vpu from HIV-1 Infected Individuals from Northern India and Their Impact on Virus Release and Cell Death.
10. Genetic architecture of HIV-1 genes circulating in north India & their functional implications.