Guoying Bing

Research interests

• Neuroinflammation &Nbsp; Mediated &Nbsp; Dopaminergic Cell Death Parkinson&Rsquo;S &Nbsp; Disease (Pd) Is A Neurodegenerative Disease Characterized By Loss Of The Dopamine-Containing &Nbsp; Neurons In The Substantia Nigra Pars Compacta (Snpc). Although The Cause Of &Nbsp; Neuronal Death Remains Unclear
• Increasing Evidence Points To The Role Of Chronic &Nbsp; Inflammatory Processes. In Order To Explore The Possibility That Microglial &Nbsp; Activation Causes Dopaminergic Cell Death In The Snpc
• Lipopolysaccharide (Lps)
• &Nbsp; A Bacterial Endotoxin That Activate Microglia
• Was Into The Substantia Nigra &Nbsp; (Sn). The Lps Injection Not Only Caused The Activation Of Microglia
• But Also &Nbsp; Resulted In A Dose-Dependent
• Selective Loss Of Dopaminergic Neurons By Apoptosis &Nbsp; In The Snpc. We Therefore Hypothesize That Lps Activates Microglia In The Sn &Nbsp; Resulting In The Release Of Cytotoxic Agents. These Agents
• In Turn
• Activate &Nbsp; Signal Transduction Pathways That Cause Neuronal Degeneration Of Dopaminergic &Nbsp; Neurons In The Sn. The Long-Term Goal Of This Study Is To Validate Lps Injection &Nbsp; As A New Animal Model Of Pd That Can Be Used To Elucidate The Etiology
• Molecular &Nbsp; Mechanisms Underlying Pd
• To Develop Novel Therapeutic Treatments For This &Nbsp
• Other Neurodegenerative Diseases. Influence Of Xenobiotic &Nbsp; Metabolites On The Neuronal Cell Death &Nbsp; Dr. Bing&Rsquo;S Laboratory Has Recently Found That A High Level Of Microsomal &Nbsp; Epoxide Hydrolase (Meh) Expression In The Brain Of Patients With Alzheimer&Rsquo;S &Nbsp; Disease As Well As The Rat Brain Following Exposure To Neurodegenerative Agents &Nbsp; Such As Kainic Acid
• Trimethyl-Tin. Relatively Little Is Known About The &Nbsp; Expression
• Function Of Meh In The Cns. However
• The Dual Function Of Meh &Nbsp; In The Activation As Well As The Inactivation Of Various Reactive Compounds &Nbsp; From Xenobiotic Metabolites Has Important Implications Regarding Its Role In &Nbsp; Brain Toxicity. The Hypothesize Is That Meh Plays A Crucial Role In The Biotransformation &Nbsp; Of Endogenous Xenobiotics And/Or Environmental Chemicals Into More Toxic Metabolites &Nbsp; Which May Cause Neuronal Degeneration In Specific Neuronal Populations. The &Nbsp; Identifying The Exact Role Of Meh As Well As The Role Of Xenobiotic Metabolites &Nbsp; In The Brain Will Be Critical In Understanding The Neurodegeneration Induced &Nbsp; By Exposure To Toxic Chemicals