Yi Yu MD

• Yi Yu is an Associate Faculty Member who works with Faculty Member Zixin Deng to recommend the scientific literature in their field.

Academic Position: 

• July 2010–present Associate Professor, School of Pharmaceutical Sciences, Wuhan University.

Publications:

1. Ding W., Ji W., Wu Y., Wu R., Liu W., Ma X., Zhang W., Xu P., Deng Z., Tang B., Yu Y.*, Zhang Q*. Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ. Nature Communications, 2017, 8(1):437. DOI: 10.1038/s41467-017-00439-1
2. Yu Y., Zhang Q., Deng Z.*, Parallel pathways in the biosynthesis of aminoglycoside antibiotics. F1000Res. 2017, 6. pii: F1000 Faculty Rev-723. doi: 10.12688/f1000research.11104.1
3. Su L, Zhang R, Kyeremeh K, Deng Z, Deng H* and Yu Y.*. Dissection of the neocarazostatin A C4 alkyl side chain biosynthesis by in vitro reconstitution. Organic & Biomolecular Chemistry, 2017, 15(18): 3843-3848
4. Su L, Lv M, Kwaku K, Deng Z, Deng H and Yu Y.*, A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation, Organic & Biomolecular Chemistry, 2016, 14:8679-8684
5. Lv M, Ji X, Zhao J, Li Y, Zhang C, Su L, Ding W, Deng Z, Yu Y.* and Zhang Q*. Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis. J AM CHEM SOC, 2016, 138(20):6427-35
6. Huang S., Elsayed S., Lv M., Tabudravu J., Rateb M., Gyampoh R., Kyeremyh K., Ebel R., Jaspars M., Deng Z., Yu Y.* and Deng H.* Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps. Chemistry & Biology, 2015, 22(12):1633-42
7. Lv Meinan, Zhao Junfeng, Deng Zixin and Yu Y.*. Characterization of the biosynthetic gene cluster for benzoxazole antibiotics A33853 reveals unusual assembly logic. Chemistry & Biology, 2015, 22(10):1313-1324
8. Huang S, Tabudravu J, Elsayed SS, Travert J, Peace D, Tong MH, Kyeremeh K, Kelly SM, Trembleau L, Ebel R, Jaspars M, Yu Y.* and Deng H*. Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins. Angew Chem Int Ed Engl. 2015, 54(43):12697-12701
9. Huang S, Tong MH, Qin Z, Deng Z, Deng H, Yu Y.*. Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137. Anticancer Agents Med Chem, 2015, 15(3):277-84.
10. Hao C.L., Huang S., Deng Z.X., Zhao C.M., Yu Y.* Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization. PLOS ONE, 2014, 9(6):e99077.