Editorial Board
Chiara Raggi
Humanitas Clinical and Research Center · Italy
Editorial leadership for Journal of Evolving Stem Cell Research ISSN 2574-4372
Research interests
- Critical Interaction Between Stem Like Compartment
- Inflammatory Component In Cholangiocarcinoma
Biography
- Since 2007, Dr. Chiara Raggi has acquired a considerable professional experience in experimental oncology studying cellular and molecular aspects of human hepatocellularcarcinoma, in particular, focusing on CSC aspects of HCC.
- Dr. Raggi holds a PhD in General Pathology (University of Pisa).
- At the end of her PhD program, she joined as a post-doctoral fellow the Laboratory of Experimental Carcinogenesis at the National Cancer Institute (NCI/NIH) directed by Dr. Thorgeirsson SS to continue her studies on human carcinogenesis.
- At the LEC, Dr Raggi’s research work has been focused on the cellular and molecular aspects of human HCC.
- In particular, Dr Raggi has concentrated her activity on CSCs aspects of HCC in addition to participating to other projects at LEC.
- Within her research studies on the CSCs aspects of HCC, Dr Raggi has examined the role of epigenetic modifications on hepatic CSCs.
- One of her recent study (Hepatology,54(3):1031-42, 2011) demonstrated that epigenetic modulation may provide a tool for prospective isolation and in-depth analysis of CSCs.
- Additionally, Dr Raggi has recently developed an innovative in vitro model to analyze CSC response to both cell microenvironment and epigenetic machinery.
- She has been able to demonstrate the importance of the interaction between epigenetic control and local microenvironment in defining the regulation of cancer stem/progenitor cells.
- Cellular context is a critical determinant in the response to DNMT1 inhibition resulting in either a long term epigenetically driven malignant reprogramming or an effective antitumor therapeutic reprogramming.
- These results identify DNA methylation as a key epigenetic regulatory mechanism determining the pool of cancer stem cells in liver cancer and possibly other solid tumors.
- This work has been submitted for publication in Hepatology journal.
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This journal is guided by Chiara Raggi (Humanitas Clinical and Research Center) and a peer-review board of practising researchers. Open access, author-retained copyright (CC BY), and a clear editorial process.