Editorial Board
Hehuang Xie Master (University of Iowa University College); Ph.D. (University of Iowa University College)
Professor, Virginia Polytechnic Institute and State University, Blacksburg, VA · United States
Editorial leadership for Journal of Hematology and Oncology Research ISSN 2372-6601
Research interests
- Dna Methylation
Biography
- Dr. Hehuang Xie graduated from the University of Iowa with Ph.D. in genetics and a master degree in computer science in 2003.
- After his graduate studies, Dr. Xie received his postdoctoral training in the field of bioinformatics at The University of Iowa and The University of Minnesota.
- In 2005, Dr. Xie joined the Cancer Biology and Epigenomics Program, Children Memorial Research Center;
- Department of Pediatrics, Northwestern University as a research faculty.
- Currently, Dr. Xie is an associate professor at the Virginia Bioinformatics Institute.
- The primary research interest of Xie's group is to understand the molecular mechanisms underlying epigenetic transitions during important biological processes associated with human complex diseases.
- Toward this goal, my group emphasizes the development of high-throughput sequencing approaches for data generation and the implementation of computational tools for -omics data analysis.
- In particular, the group is interested in strategies to monitor the fidelity of DNA methylation inheritance, assess methylation variation within and between cell populations, identify true epimutations, and, eventually, discover novel therapies.
- Our previous studies include bio-technique development to facilitate targeted epigenome sequencing, CpG islands and Alu repeats in particular ; and model establishment to assess DNA methylation variations and simulate epigenetic state transitions during stem cell differentiation, reprogramming and disease genesis.
- We have successfully applied techniques and bioinformatics tools to identify diagnosis markers for diseases.
Selected publications
- DynamicAluMethylation during Normal Development, Aging, and Tumorigenesis 2014 cited 62×
- Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells 2018 cited 20×
- Folate regulates RNA m5C modification and translation in neural stem cells 2022 cited 19×
- Systematic evaluation of parameters in RNA bisulfite sequencing data generation and analysis 2022 cited 18×
- Risk of Excess Maternal Folic Acid Supplementation in Offspring 2024 cited 17×
- Perinatal Acetaminophen Exposure and Childhood Attention-Deficit/Hyperactivity Disorder (ADHD): Exploring the Role of Umbilical Cord Plasma Metabolites in Oxidative Stress Pathways 2021 cited 10×
Ranked by citation impact (Crossref) where available, newest otherwise · verified via ORCID.
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This journal is guided by Hehuang Xie (Professor, Virginia Polytechnic Institute and State University, Blacksburg, VA) and a peer-review board of practising researchers. Open access, author-retained copyright (CC BY), and a clear editorial process.