Prasenjit Guchhait Ph.D

Research interests

• Dr. Guchhait Has Long-Standing Interest In Thrombosis
• Cardiovascular Research. His Research Is Focused On The Complex Mechanism Of Thrombosis
• Vasoocclusion
• Cardiovascular Impairments In Patients With Sickle Cell Disease
• Thalassemia
• Hemolytic Uremic Syndrome. He Is Working On The Molecular Mechanism That Links Intravascular-Hemolysis
• The Above Clinical Events. More Specifically
• How Excessive Extracellular Hemoglobin Promotes Above Clinical Crises Events Under Pathophysiological Conditions. His Research Describes That Excessive Extracellular Hemoglobin Blocks The Cleavage Of Von Willebrand Factor (Vwf)
• Promotes Accumulation Of Ultralarge Vwf Multimers In Plasma
• On Endothelium. The Ultralarge Vwf Multimers Are Hyperactive
• Are Associated With Above Clinical Complications In Patients. His Research Also Focused On Identifying Adhesive Molecules On Blood Cells Surface
• On Vascular Endothelium That Mediates Unusual Cell Adhesion
• Culminate Vascular Occlusion In Patients. His Research Describe That Increased Exposure Of Adhesive Membrane Lipid
• Sulfatide On Activated-Platelet Surface Promotes Platelets Adhesion
• Thrombosis. The Increased Exposure Of Sulfatide On Sickled-Red Blood Cells Surface Mimics The Sickle Cell Adhesion To The Endothelium
• Sub-Endothelial Matrices. His Research Is Also Focused On Translation Of Above Molecular
• Genomic Findings To Therapeutic Practice. He Has Designed A Recombinant Small Single-Chain Antibody Against Sulfatide That Inhibits Platelets Adhesion To Endothelium. Currently In Vivo Experiments Are In Progress To Determine The Effects Of Anti-Sulfatide Scfvs On Blood Cells Adhesion
• Vasoocclusion In Mice With Sickle Cell Disease

Biography